Prevention of Mother to Child Transmission TUAC1

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Type:
Oral Abstract Session Back
Venue: Session Room 4
Time: 14:30 - 16:00, 21.07.2009
Code: TUAC1
Chairs: Ruth Nduati, Kenya
Laura Guay, United States
Session recording provided by International AIDS Society



Presentations in this session:

14:30
TUAC101
Abstract
Extended use of highly active antiretroviral therapy (HAART) during pregnancy in Southern Africa is highly protective in HIV-1 prevention of mother-to-child-transmission (PMTCT) also in women with higher CD4 cell counts
Presented by Leonardo Palombi, Italy
M.C. Marazzi1,2, G. Liotta3, J. Haswell4, I. Zimba5, K. Nielsen-Saines6, M. Maulidi7, N. Abdul Magid5, D. Thole8, E. Buonomo3, P. Scarcella3, G. Paturzo9, A.M. Doro Altan3, S. Mancinelli3, L. Palombi1,3
1Community of Sant'Egidio, DREAM program, Rome, Italy, 2LUMSA University, Rome, Italy, 3University of Tor Vergata, Public Health, Rome, Italy, 4DREAM Program, Community of S. Egidio, Blantyre, Malawi, 5DREAM Program, Community of S. Egidio, Maputo, Mozambique, 6UCLA, Pediatrics, Los Angeles, United States, 7DREAM Program, Community of S. Egidio, Lilongwe, Malawi, 8DREAM Program, Community of S. Egidio, Balaka, Malawi, 9DREAM Program, Community of S. Egidio, Rome, Italy

14:45
TUAC102
Abstract
Favorable pregnancy outcomes with reduction of abortion, stillbirth, and prematurity rates in a large cohort of HIV+ women in Southern Africa receiving highly active antiretroviral therapy (HAART) for prevention of mother-child-transmission (PMTCT)
Presented by Leonardo Palombi, Italy
M.C. Marazzi1,2, L. Palombi1,3, K. Nielsen-Saines4, J. Haswell5, I. Zimba6, M. Maulidi7, N. Abdul Magid6, L. Richard5, E. Buonomo3, P. Scarcella3, S. Ceffa1, G. Paturzo1, P. Narciso8, G. Liotta3
1DREAM Program, Community of S. Egidio, Rome, Italy, 2LUMSA University, Rome, Italy, 3University of Tor Vergata, Public Health, Rome, Italy, 4UCLA, Pediatrics, Los Angeles, United States, 5DREAM Program, Community of S. Egidio, Blantyre, Malawi, 6DREAM Program, Community of S. Egidio, Maputo, Mozambique, 7DREAM Program, Community of S. Egidio, Lilongwe, Malawi, 8INMI 'L.Spallanzani', Rome, Italy

15:00
TUAC103
Abstract
Powerpoint
Presentation with late stage HIV disease at diagnosis of HIV infection in pregnancy
Presented by Claire Nicola Thorne, United Kingdom
C.N. Thorne1, M.-L. Newell1,2, European Collaborative Study on HIV-infected pregnant women and their children
1University College London, Institute of Child Health, London, United Kingdom, 2Africa Center for Health and Population Studies, UKZN, Durban, South Africa

15:15
TUAC104
Abstract
Powerpoint
Diarrhea morbidity and mortality increases with weaning prior to 6 months among uninfected infants born to HIV-infected mothers in Zambia
Presented by Ashraf Fawzy, United States
A. Fawzy1, S. Arpadi1, G. Aldrovandi2, C. Kankasa3, M. Sinkala4, M. Mwiya3, D. Thea5, L. Kuhn1, Zambia Exclusive Breastfeeding Study Group
1Columbia University - Mailman School of Public Health, New York, United States, 2Childrens Hospital, Los Angeles, United States, 3University Teaching Hospital, Lusaka, Zambia, 4Lusaka District Health Management Team, Lusaka, Zambia, 5Boston University, Boston, United States

15:30
TUAC105
Abstract
Powerpoint
Male partner HIV-1 testing and antenatal clinical attendance associated with reduced infant HIV-1 acquisition and mortality
Presented by Adam Aluisio, United States
A. Aluisio1, R. Bosire2, G. John-Stewart3, D. Mbori-Ngacha4, C. Farquhar5
1National Instititues of Health, Fogarty International Center, Bethesda, United States, 2Kenya Institute of Medical Research (KEMRI), Nairobi, Kenya, 3University of Washington, Departments of Medicine, Epidemiology and Global Health, Seattle, United States, 4University of Nairobi, Department of Pediatrics, Nairobi, Kenya, 5University of Washington, Departments of Medicine and Epidemiology, Seattle, United States



Powerpoints presentations


Presentation with late stage HIV disease at diagnosis of HIV infection in pregnancy - Thorne

Diarrhea morbidity and mortality increases with weaning prior to 6 months among uninfected infants born to HIV-infected mothers in Zambia - Fawzy

Male partner HIV-1 testing and antenatal clinical attendance associated with reduced infant HIV-1 acquisition and mortality - Aluisio



Rapporteur report

Track C report by Vivian Black


Dr Palombi presented observational data from the Malawi  and Mozambique DREAM (Drug Resource Enhancement against AIDS and Malnutrition) cohorts. In an observational study of >3,000 mother-infant pairs where the mother was provided nevirapine-based HAART 14-25 weeks prior to delivery, HIV-1 transmission within 30 days of delivery was <1% in infants of women who received at least one dose of HAART prior to delivery.  The authors argue that this approach was safe and effective in women with CD4+ counts > 350. No data was presented on transmission associated with breast feeding. In a second paper from this cohort, a review of >3,000 files of pregnant women who did or did not receive HAART, HAART for > 30 days was shown to be associated with reduced rates of maternal mortality, miscarriage and stillbirth. 

 

Claire Thorne presented on late diagnosis of HIV in a cohort of 1,256 pregnant women from Western Europe. The paper highlighted the increasing proportion of women with late stage HIV disease diagnosed during pregnancy. Late diagnosis was associated with poor pregnancy outcomes.

 

Ashraf Fawzy presented data from the ZEBS cohort in Zambia which showed diarrhoea morbidity and mortality in 593 infants randomised to either rapid weaning at 4 months compared to exclusive breast feeding till 6 months. In the weaned group, diarrhoea, hospitalisation and death from diarrhoeal illness increased from 4 months in uninfected infants and was 3 fold higher than in the breastfeeding group.

 

Limited data is available on male attendance in uptake of PMTCT interventions. Adam Aluisio presented data from a Kenyan study which showed that male attendance during antenatal care and a history of male partner HIV testing improved HIV free survival in the infants. The mechanism of this association needs to be explored further.




   

   

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